Aayush GuptaVitiligo and pigment biology
Vitiligo skin carries a lower ultraviolet signature than non-melanoma skin cancers, and its epidermis shows a strong anti-skin cancer signature in miRNA networks. The long noncoding RNA MALAT1 and the microRNA miR-31-5p both protect melanin-deficient vitiligo keratinocytes against ultraviolet damage to DNA. An ANRF grant now funds an immune-competent 3D human skin model of vitiligo.
15 papers2 clinical trials1 grant
Papers
Newest first. Every paper is also on the publications page.
- Nevus of OtaJournal of the American Academy of Dermatology2026DOI
- microRNA miR-31-5p confers protection to melanin-deficient vitiligo keratinocytes against UV-B induced DNA damage by activating autophagy machineryScientific Reports2026DOI
- Minimal erythema dose variability in Indian skin: clinical implications across pigmentary and inflammatory dermatosesClinical and Experimental Dermatology2025Senior authorDOI
- Stem cell factor-mediated upregulation of SIRT1 protects melanin-deprived keratinocytes against UV-induced DNA damage in individuals with vitiligoThe FASEB Journal2024DOI
- Meta‐analysis reveals a lower ‘UV signature’ in vitiligo skin compared to non‐melanoma skin cancersExperimental Dermatology2024DOI
- VitiligoJournal of the American Academy of Dermatology2024Senior authorDOI
- Whole-Exome Sequencing of Vitiligo Lesions Indicates Lower Burden of Somatic Variations: Implications in Risk for Nonmelanoma Skin CancersJournal of Investigative Dermatology2022DOI
- Genome-wide profiling reveals pervasive transcriptional alterations in fibroblasts derived from lesional skin in vitiligo including a reduced potential to proliferateExperimental Dermatology2022DOI
- Differential regulation of miR-21-5p delays wound healing of melanocyte-deprived vitiligo skin by modulating the expression of tumor-suppressors PDCD4 and MaspinJournal of Cellular Physiology2021DOI
- Integrated analysis of miRNA‐mRNA networks reveals a strong anti‐skin cancer signature in vitiligo epidermisExperimental Dermatology2021DOI
- The long noncoding RNA MALAT1 suppresses miR‐211 to confer protection from ultraviolet‐mediated DNA damage in vitiligo epidermis by upregulating sirtuin 1British Journal of Dermatology2020DOI
- Lesional skin in vitiligo exhibits delayed in vivo reepithelialization compared to the nonlesional skinWound Repair and Regeneration2020First authorDOI
- Correlating impairment of quality of life and severity of melasma: A cross-sectional study of 141 patientsIndian Journal of Dermatology2018First authorDOI
- Mapping architectural and transcriptional alterations in non-lesional and lesional epidermis in vitiligoScientific Reports2017DOI
- Quality of life in vitiligo: Relationship to clinical severity and demographic dataPigment International2017First authorDOI
Clinical trials
Research grants
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Canonical page: https://aayushgupta.co/research/vitiligo-and-pigment-biology